![]() ![]() The number of differentially expressed transcripts was notably higher in the female than in the male rats (702 vs. 571). In the first step, we explored differentially expressed transcripts in the adrenal ZG and ZF/R. Subsequently, we performed functional annotation clustering using the Gene Ontology (GO) and Database for Annotation, Visualization and Integrated Discovery (DAVID). The microarray data were compared by fold change with significance according to moderated t-statistics. Transcriptome identification was carried out using the Affymetrix® Rat Gene 1.1 ST Array. Twelve-week-old rats of both genders were used and samples were taken from the zona glomerulosa (ZG) and zona fasciculata/reticularis (ZF/R) zones. In this study, to explore the molecular background of these differences, we defined zone- and sex-specific transcripts in adult male and female (estrous cycle phase) rats. The molecular bases of these sex-related differences are poorly understood. In adult rats, the adrenal weight and the average volume of zona fasciculata cells of females are larger and secrete greater amounts of corticosterone than those of males. ![]() Notable sex-related differences exist in mammalian adrenal cortex structure and function. ![]()
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